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Home/Compounds/Pharmaceutical Intermediate/N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]purin-6-yl]benzamide
C47H51FN7O7P
875.9 g/mol
Pharmaceutical Intermediate

N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]purin-6-yl]benzamide

CAS136834-22-5EC890-259-3
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

This compound is a perbrominated diphenyl ether derivative used as an intermediate in the synthesis of oligonucleotides. It features a complex structure with multiple aromatic rings, ether linkages, and a protected nucleoside core.

Pharmaceutical intermediate for oligonucleotide synthesis

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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CAS 136834-22-5

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Related Compounds

StrongStructure SimilarSimilarity 0.88

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pharmaceutical intermediate

StrongStructure SimilarSimilarity 0.86

N-[9-[(2R,3R,4R,5R)-4-[bis(4-methoxyphenyl)-phenyl-methoxy]-5-[[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxymethyl]-3-fluoro-tetrahydrofuran-2-yl]purin-6-yl]benzamide

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SimilarStructure SimilarSimilarity 0.84

N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

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pharmaceutical intermediate

SimilarStructure SimilarSimilarity 0.84

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N-[9-[(2R,6S)-6-[[chloro(dimethylamino)phosphoryl]oxymethyl]-4-tritylmorpholin-2-yl]-6-oxo-1H-purin-2-yl]-2-phenylacetamide

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pharmaceutical intermediate

Identifiers
IUPAC Name

N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]purin-6-yl]benzamide

InChIKey

VCCMVPDSLHFCBB-MSIRFHFKSA-N

SMILES

CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1F)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

Synonyms (23)
  • 2'-F-Bz-A Phosphoramidite
  • 2'-F-Bz-dA Phosphoramidite
  • 2'-Fluoro-Bz-A-CEP
  • 2'-Fluoro-dA CEP
  • Cytidine Impurity 73
  • Dmt-2'fluoro-da(bz) amidite