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Home/Compounds/Pharmaceutical Intermediate/N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
C35H36FN5O7
657.7 g/mol
Pharmaceutical Intermediate

N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

CAS144089-96-3
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

This compound is a protected 2'-deoxyguanosine derivative used as a building block in the solid-phase chemical synthesis of oligonucleotides. It features a 5'-O-DMTr protecting group and an isobutyryl (iBu) group on the guanine base, along with a 2'-fluoro substitution, which enhances stability for research and manufacturing applications.

Pharmaceutical intermediate for oligonucleotide synthesisBuilding block in solid-phase DNA/RNA synthesis

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

StrongStructure SimilarSimilarity 0.85

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SimilarStructure SimilarSimilarity 0.75

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Identifiers
IUPAC Name

N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChIKey

QQQXVSXVBFQISZ-UNVYQVKTSA-N

SMILES

CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)F

Synonyms (15)
  • 5'-DMT-2'-F-ibu-dG
  • Cytidine Impurity 64
  • DMT-2'-F-iBu-G