C35H37N5O7
639.7 g/mol
Pharmaceutical Intermediate
Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)-
CAS68892-41-1EC272-615-4
Category
Pharmaceutical Intermediate
Compound Class
Other
Primary Use
Pharmaceutical Intermediate
This compound is a protected nucleotide building block used in the synthesis of oligonucleotides. It features a purine base with an isobutyryl amide protecting group and a dimethoxytrityl (DMT) group for temporary protection of the 5'-hydroxyl, making it suitable for solid-phase DNA/RNA synthesis.
Building block for automated oligonucleotide synthesisIntermediate in the production of modified DNA or RNA sequences
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 68892-41-1
Related Compounds
SimilarStructure SimilarSimilarity 0.75
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-methyl-N-(2-methylpropanoyl)guanosine
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SimilarStructure SimilarSimilarity 0.75
N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
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ReferenceSame Category
1-(4-Chloromethyl-2-thiazoyl)guanidine Hydrochloride Salt
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Referencesame scaffold
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-N-(2-methyl-1-oxopropyl)guanosine
CAS251647-50-4
pharmaceutical intermediate
Referencesame scaffold
5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(tert-butyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)guanosine
CAS81279-39-2
pharmaceutical intermediate
Safety Reference
H411Toxic to aquatic life with long lasting effects
Identifiers
IUPAC Name
N-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide
InChIKey
RMQXDNUKLIDXOS-ZGIBFIJWSA-N
SMILES
CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@H]3C[C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O
Synonyms (18)
- 5'-O-DMT-N2-ibu-dG
- N2-iBu-DMT-dG
- iBu-DMT-dG