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Home/Compounds/Pharmaceutical Intermediate/Fmoc-L-glutamic acid 5-tert-butyl ester
C24H27NO6
425.5 g/mol
Pharmaceutical Intermediate

Fmoc-L-glutamic acid 5-tert-butyl ester

CAS71989-18-9
Category
Pharmaceutical Intermediate
Compound Class
Peptide
Primary Use
Pharmaceutical Intermediate

Fmoc-L-glutamic acid 5-tert-butyl ester is a protected amino acid derivative used in solid-phase peptide synthesis. Its structure incorporates both an Fmoc (9-fluorenylmethoxycarbonyl) protecting group on the amino terminus and a tert-butyl ester protecting group on the side-chain carboxyl, enabling selective deprotection during peptide chain assembly.

Protected building block for solid-phase peptide synthesisReagent in the manufacture of peptide-based pharmaceuticals

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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CAS 71989-18-9

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Related Compounds

StrongSame Parent

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StrongStructure SimilarSimilarity 0.88

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SimilarStructure SimilarSimilarity 0.81

Fmoc-Glu(OtBu)-Phe-OH

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ReferenceSame Category

N-Fmoc-N'-Boc-L-Lysine

CAS71989-26-9

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ReferenceSame Category

Fmoc-L-Methionine

CAS71989-28-1

pharmaceutical intermediate

ReferenceSame Category

(2S)-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid

CAS71989-31-6

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ReferenceSame Category

Fmoc-O-tert-Butyl-L-serine

CAS71989-33-8

pharmaceutical intermediate

Referencestereoisomer of

Fmoc-D-glutamic acid gamma-tert-butyl ester

CAS104091-08-9

pharmaceutical intermediate

Identifiers
IUPAC Name

(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid

InChIKey

OTKXCALUHMPIGM-FQEVSTJZSA-N

SMILES

CC(C)(C)OC(=O)CC[C@@H](C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

Synonyms (21)
  • Fmoc-Glu(OtBu)-OH
  • Fmoc-Glu(OtBu)-OH,Nonhydrate
  • Fmoc-Glu(OtBu)-OH.nH2O
  • Fmoc-Glu(tBu)
  • Fmoc-L-Glu(OtBu)
  • Fmoc-L-Glu(OtBu)-OH
  • fmoc-glu(otbu)