C22H25NO5
383.4 g/mol
Pharmaceutical IntermediateWarning
O-(tert-Butyl)-N-((9H-fluoren-9-ylmethoxy)carbonyl)-L-serine
CAS71989-33-8EC276-260-6
Category
Pharmaceutical Intermediate
Compound Class
Peptide
Primary Use
Pharmaceutical Intermediate
This compound is an N-protected serine derivative commonly employed as a building block in solid-phase peptide synthesis. Its structure incorporates a fluorenylmethoxycarbonyl (Fmoc) protecting group on the amino function and a tert-butyl ether protecting group on the side-chain hydroxyl, enabling selective deprotection during peptide chain assembly.
peptide synthesis building blockresearch reagent for pharmaceutical intermediate manufacturing
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
SimilarStructure SimilarSimilarity 0.77
Fmoc-Ser(tBu)-Gly-OH
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SimilarStructure SimilarSimilarity 0.75
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methyl-L-leucine
CAS139551-74-9
pharmaceutical intermediate
SimilarStructure SimilarSimilarity 0.73
Fmoc-L-Aspartic acid beta-tert-butyl ester
CAS71989-14-5
pharmaceutical intermediate
ApplicationSame Use
Fmoc-D-alanine
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ApplicationSame Use
Fmoc-alpha-methylalanine
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ApplicationSame Use
N-Fmoc-S-trityl-D-cysteine
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ApplicationSame Use
Boc-N-methyl-D-alanine
CAS19914-38-6
pharmaceutical intermediate
ReferenceSame Category
Fmoc-O-tert-butyl-L-tyrosine
CAS71989-38-3
pharmaceutical intermediate
Related Reading
Safety Reference
Warning
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
H413May cause long lasting harmful effects to aquatic life
Customs Tariff Classification
The international HS code for O-(tert-Butyl)-N-((9H-fluoren-9-ylmethoxy)carbonyl)-L-serine (CAS 71989-33-8) is 2924.29.
HS code (international, 6-digit)
2924.29
EU CN code (8-digit)
2924 29 70
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoic acid
InChIKey
REITVGIIZHFVGU-UHFFFAOYSA-N
SMILES
CC(C)(C)OCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13
Synonyms (6)
- Fmoc-D-Ser(But)-OH
- N-Fmoc-O-tert-butyl-DL-serine
- O-tert-Butyl-N-Fmoc-L-serine
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