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Home/Compounds/Research Reagent/5'-O-DMT-2'-TBDMS-Uridine
C36H44N2O8Si
660.8 g/mol
Research Reagent

5'-O-DMT-2'-TBDMS-Uridine

CAS81246-80-2
Category
Research Reagent
Compound Class
Heterocycle
Primary Use
Research Compound

5'-O-DMT-2'-TBDMS-Uridine is a protected uridine derivative specifically designed for use as a building block in the chemical synthesis of oligonucleotides. It features a dimethoxytrityl (DMT) protecting group at the 5'-hydroxyl and a tert-butyldimethylsilyl (TBDMS) group at the 2'-hydroxyl, enabling controlled assembly of RNA sequences during solid-phase synthesis.

Building block for automated oligonucleotide synthesisReagent for RNA synthesis

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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CAS 81246-80-2

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Identifiers
IUPAC Name

1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione

InChIKey

KVHQIELPHWJPSY-WXQJYUTRSA-N

SMILES

CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O

Synonyms (14)
  • 5'-DMT-2'-TBDMS-AoUO
  • 5'-DMT-2'-TBDMS-RU
  • 5'-DMT-2'-TBDMS-Uridine
  • 5'-DMT-2'-tBDSilyl Uridine
  • 5'-O-DMT-2'-TBDMS-Uridine
  • TBS-rU