C20H21CaN7O7
511.5 g/mol
APIDanger
LEVOLEUCOVORIN CALCIUM
CAS80433-71-2
Category
API
Compound Class
Organic Acid
Primary Use
Pharmaceutical Raw Material
Levoleucovorin calcium is an active metabolite of folic acid and the levo isomer of leucovorin calcium. As an active pharmaceutical ingredient, it is used to counteract the toxic effects of folate antagonist agents and to potentiate the activity of fluorouracil in pharmaceutical manufacturing.
rescue agent in folate antagonist therapypotentiating agent for fluorouracil
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
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Referencestereoisomer of
Leucovorin calcium
CAS1492-18-8
pharmaceutical raw material
Referencestereoisomer of
Folinic acid
CAS58-05-9
pharmaceutical raw material
Safety Reference
Danger
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
Customs Tariff Classification
The international HS code for LEVOLEUCOVORIN CALCIUM (CAS 80433-71-2) is 2936.29.
HS code (international, 6-digit)
2936.29
EU CN code (8-digit)
2936 29 00
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
calcium (2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
InChIKey
KVUAALJSMIVURS-QNTKWALQSA-L
SMILES
C1[C@@H](N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Ca+2]
Synonyms (28)
- Calcium levofolinate (INN)
- Levoleucovorin calcium (USAN)
- CALCIUM LEVOFOLINATE (MART.)
- CL 307,782
- Calcium levofolinate
- Calcium levofolinate (6s,l)
- Elvorine
- Isovorin
- L-Leucovorin calcium
- LEVOLEUCOVORIN CALCIUM
- Levofolinate calcium
- Levofolinate calcium (JAN)
- Levofolinate de calcium
- Levofolinato de calcio
- Levoleucovorin calcium salt
- calcium (6s)-folinate
- calcium levoleucovorin
- levoleucovorin injection
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