C12H22F6N6OP2
442.28 g/mol
Research ReagentDanger
Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate
CAS56602-33-6EC260-279-1
Category
Research Reagent
Compound Class
Heterocycle
Primary Use
Research Compound
Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate, commonly known as BOP, is a reagent widely used for the synthesis of amides from carboxylic acids and amines in peptide synthesis. It is prepared from 1-hydroxybenzotriazole and a chlorophosphonium reagent under basic conditions and offers advantages by minimizing side reactions such as dehydration of asparagine or glutamine residues.
Peptide coupling reagentSynthesis of amides from carboxylic acids and amines
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Safety Reference
Danger
H228Flammable solid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
Customs Tariff Classification
The international HS code for Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (CAS 56602-33-6) is 2933.99.
HS code (international, 6-digit)
2933.99
EU CN code (8-digit)
2933 99 80
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
benzotriazol-1-yloxy-tris(dimethylamino)phosphanium hexafluorophosphate
InChIKey
MGEVGECQZUIPSV-UHFFFAOYSA-N
SMILES
CN(C)[P+](N(C)C)(N(C)C)ON1C2=CC=CC=C2N=N1.F[P-](F)(F)(F)(F)F
Synonyms (26)
- BOP hexafluorophosphate
- Bop reagent
- Castro's Reagent
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