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Home/Compounds/Research Reagent/HBTU
C11H16F6N5OP
379.24 g/mol
Research ReagentWarning

2-Hbtu

CAS94790-37-1EC619-076-7
Category
Research Reagent
Compound Class
Heterocycle
Primary Use
Research Compound

2-Hbtu is a peptide coupling reagent used in synthetic organic chemistry to activate carboxylic acids for amide bond formation. It is commonly employed in laboratory research for peptide synthesis.

activator for peptide synthesiscoupling reagent in peptide synthesis

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Reading

HATU, HBTU and T3P: How Three Peptide Coupling Reagents Actually Differ — Mechanism, Epimerization, and Handling

HATU, HBTU and T3P dominate peptide and pharma amide-bond formation, but they differ in reactivity, epimerization, workup and — critically — regulatory status. Grounded in the El-Faham & Albericio review and the ACS GCIPR safety assessment, this article sets out how the three reagents actually differ, why HATU couples cleaner than HBTU, and why T3P is a CWC Schedule 2 controlled chemical while HATU and HBTU are not.

Read more

Safety Reference

Flammable
Flammable
Harmful
Harmful
Warning
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H228Flammable solid

Customs Tariff Classification

The international HS code for 2-Hbtu (CAS 94790-37-1) is 2933.99.

HS code (international, 6-digit)

2933.99

EU CN code (8-digit)

2933 99 80

Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.

Identifiers
IUPAC Name

[dimethylamino-(3-oxidobenzotriazol-3-ium-1-yl)methylidene]-dimethylazanium hexafluorophosphate

InChIKey

BSKUEERROYGAFF-UHFFFAOYSA-N

SMILES

CN(C)C(=[N+](C)C)N1C2=CC=CC=C2[N+](=N1)[O-].F[P-](F)(F)(F)(F)F

Synonyms (13)
  • HBTU
  • N-HBTU
  • 2-Hbtu

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