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Home/Compounds/Research Reagent/Propylphosphonic anhydride
C9H21O6P3
318.18 g/mol
Research ReagentDanger

Propylphosphonic anhydride

CAS68957-94-8EC422-210-5
Category
Research Reagent
Compound Class
Heterocycle
Primary Use
Research Compound

Propylphosphonic anhydride is the trimeric anhydride of n-propylphosphonic acid. It is widely used as a reagent in peptide synthesis to activate carboxylic acids for reaction with amines.

peptide coupling reagentcarboxylic acid activation in peptide synthesis

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Reading

HATU, HBTU and T3P: How Three Peptide Coupling Reagents Actually Differ — Mechanism, Epimerization, and Handling

HATU, HBTU and T3P dominate peptide and pharma amide-bond formation, but they differ in reactivity, epimerization, workup and — critically — regulatory status. Grounded in the El-Faham & Albericio review and the ACS GCIPR safety assessment, this article sets out how the three reagents actually differ, why HATU couples cleaner than HBTU, and why T3P is a CWC Schedule 2 controlled chemical while HATU and HBTU are not.

Read more

Safety Reference

Corrosive
Corrosive
Harmful
Harmful
Danger
H314Causes severe skin burns and eye damage
H290May be corrosive to metals
H317May cause an allergic skin reaction
H318Causes serious eye damage

Customs Tariff Classification

The international HS code for Propylphosphonic anhydride (CAS 68957-94-8) is 2931.46.

HS code (international, 6-digit)

2931.46

EU CN code (8-digit)

2931 46 00

Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.

Identifiers
IUPAC Name

2,4,6-tripropyl-1,3,5,2lambda5,4lambda5,6lambda5-trioxatriphosphinane 2,4,6-trioxide

InChIKey

PAQZWJGSJMLPMG-UHFFFAOYSA-N

SMILES

CCCP1(=O)OP(=O)(OP(=O)(O1)CCC)CCC

Synonyms (30)
  • propylphosphonic anhydride

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