C18H28F6N6OP2
520.4 g/mol
Research ReagentWarning
PyBOP
CAS128625-52-5
Category
Research Reagent
Compound Class
Other
Primary Use
Research Compound
PyBOP is a reagent used for coupling carboxylic acids with amines to form amides, particularly in peptide synthesis. It is prepared from 1-hydroxybenzotriazole and a chlorophosphonium reagent under basic conditions.
Peptide synthesis reagentAmide bond formation in organic synthesis
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Safety Reference
Warning
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H335May cause respiratory irritation
H410Very toxic to aquatic life with long lasting effects
Identifiers
IUPAC Name
benzotriazol-1-yloxy(tripyrrolidin-1-yl)phosphanium hexafluorophosphate
InChIKey
VIAFLMPQBHAMLI-UHFFFAOYSA-N
SMILES
C1CCN(C1)[P+](N2CCCC2)(N3CCCC3)ON4C5=CC=CC=C5N=N4.F[P-](F)(F)(F)(F)F
Synonyms (32)
- Dibenz-(b,f)-1,4-oxazephine
- PyBOP
- bopp
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