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Home/Compounds/Pharmaceutical Intermediate/5'-O-DMT-N2-DMF-dG
C34H36N6O6
624.7 g/mol
Pharmaceutical Intermediate

5'-O-DMT-N2-DMF-dG

CAS40094-22-2
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

This compound is a protected deoxyguanosine derivative commonly used in the solid-phase synthesis of oligonucleotides. The 5'-O-DMT (dimethoxytrityl) and N2-DMF (dimethylformamidine) protecting groups shield the 5'-hydroxyl and the exocyclic amine of guanine, respectively, during chain elongation.

Nucleoside protecting group intermediate for oligonucleotide synthesis

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Identifiers
IUPAC Name

N'-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChIKey

YTRIMRXIMVGPAL-ZGIBFIJWSA-N

SMILES

CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2[C@H]3C[C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O

Synonyms (5)
  • 5'-O-DMT-N2-DMF-dG