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Home/Compounds/Pharmaceutical Intermediate/(S)-N1-(4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-((TETRAHYDROFURAN-3-YL)OXY)QUINAZOLIN-6-YL)-N2,N2-DIMETHYLOXALAMIDE
C22H21ClFN5O4
473.9 g/mol
Pharmaceutical Intermediate

(S)-N1-(4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-((TETRAHYDROFURAN-3-YL)OXY)QUINAZOLIN-6-YL)-N2,N2-DIMETHYLOXALAMIDE

CAS2223677-66-3
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

This compound is a pharmaceutical intermediate featured in PubChem as this compound, with a molecular weight of 473. 13 and a logP of 3.

pharmaceutical intermediate for afatinib impurity synthesislaboratory research reagent for impurity profiling

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

StrongStructure SimilarSimilarity 0.87

N1,N2-Bis(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)oxalamide

CAS2223677-65-2

pharmaceutical intermediate

SimilarStructure SimilarSimilarity 0.74

Afatinib Impurity AFT-8

CAS2323570-72-3

pharmaceutical raw material

SimilarStructure SimilarSimilarity 0.74

(R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide

CAS2413212-23-2

pharmaceutical intermediate

SimilarStructure SimilarSimilarity 0.73

N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-3,4-bis(dimethylamino)butanamide

CAS2414260-31-2

pharmaceutical intermediate

ReferenceSame Category

(S)-4-Methyloxazolidine-2,5-dione

CAS2224-52-4

pharmaceutical intermediate

ReferenceSame Category

1-(4-chlorophenyl)-3-oxoisoindoline

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pharmaceutical intermediate

ReferenceSame Category

4-(4-chlorophenyl)-1H-2,3-benzoxazin-1-one

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pharmaceutical intermediate

ReferenceSame Category

2-Hydroxy-3-trifluoromethylpyridine

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pharmaceutical intermediate

Identifiers
IUPAC Name

N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-N',N'-dimethyloxamide

InChIKey

TXTARPMHKVXFGC-ZDUSSCGKSA-N

SMILES

CN(C)C(=O)C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4

Synonyms (8)
  • Afatinib Impurity 114
  • Afatinib Impurity CSEJXA