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Home/Compounds/Pharmaceutical Intermediate/N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-3,4-bis(dimethylamino)butanamide
C26H32ClFN6O3
531 g/mol
Pharmaceutical Intermediate

N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-3,4-bis(dimethylamino)butanamide

CAS2414260-31-2
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

This compound is a quinazoline derivative used as a pharmaceutical reference impurity standard. It is structurally related to afatinib and is employed in quality control and analytical testing.

Pharmaceutical reference impurity standardQuality control testing in pharmaceutical manufacturing

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

StrongStructure SimilarSimilarity 0.86

Afatinib Impurity AFT-8

CAS2323570-72-3

pharmaceutical raw material

StrongStructure SimilarSimilarity 0.86

(R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((R)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)-3-hydroxybutanamide

CAS2413212-23-2

pharmaceutical intermediate

SimilarStructure SimilarSimilarity 0.73

(S)-N1-(4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-((TETRAHYDROFURAN-3-YL)OXY)QUINAZOLIN-6-YL)-N2,N2-DIMETHYLOXALAMIDE

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pharmaceutical intermediate

ReferenceSame Category

1-(((2R,3S)-2-(2,5-difluorophenyl)-3-methyloxiran-2-yl)methyl)-1H-1,2,4-triazole

CAS241479-73-2

pharmaceutical intermediate

ReferenceSame Category

(alphaS,betaR)-beta-(2,5-Difluorophenyl)-beta-hydroxy-alpha-methyl-1H-1,2,4-triazole-1-butanenitrile

CAS241479-74-3

pharmaceutical intermediate

ReferenceSame Category

IFosfamide impurity B

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pharmaceutical intermediate

ReferenceSame Category

(+/-)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol

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pharmaceutical intermediate

Identifiers
IUPAC Name

N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-3,4-bis(dimethylamino)butanamide

InChIKey

VZAJTMWUJFLJIB-ZVAWYAOSSA-N

SMILES

CN(C)CC(CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4)N(C)C

Synonyms (3)
  • Afatinib Impurity 43