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Home/Compounds/Pharmaceutical Intermediate/N1,N2-Bis(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)oxalamide
C38H30Cl2F2N8O6
803.6 g/mol
Pharmaceutical Intermediate

N1,N2-Bis(4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)oxalamide

CAS2223677-65-2
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

This compound is a pharmaceutical intermediate specifically used in the manufacturing of impurities related to Afatinib. It features a complex organic structure containing multiple aromatic rings and amide functional groups, indicating a high molecular weight and potential for use in specialized chemical synthesis.

pharmaceutical intermediate for Afatinib impurity synthesisresearch compound in pharmaceutical manufacturing

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

StrongStructure SimilarSimilarity 0.87

(S)-N1-(4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-((TETRAHYDROFURAN-3-YL)OXY)QUINAZOLIN-6-YL)-N2,N2-DIMETHYLOXALAMIDE

CAS2223677-66-3

pharmaceutical intermediate

SimilarStructure SimilarSimilarity 0.82

(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide (Afatinib Impurity)

CAS2223677-64-1

pharmaceutical intermediate

SimilarStructure SimilarSimilarity 0.79

(S)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)formamide (Afatinib Impurity)

CAS2223677-60-7

research compound

SimilarStructure SimilarSimilarity 0.75

P-[2-[[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]amino]-2-oxoethyl]phosphonic acid diethyl ester

CAS618061-76-0

pharmaceutical raw material

ApplicationSame Use

(S,E)-2-((3-Chloro-4-fluorophenyl)(6-(4-(dimethylamino)but-2-enamido)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-yl)amino)malonic acid

CAS2413212-27-6

pharmaceutical intermediate

ReferenceSame Category

(S)-4-Methyloxazolidine-2,5-dione

CAS2224-52-4

pharmaceutical intermediate

ReferenceSame Category

1-(4-chlorophenyl)-3-oxoisoindoline

CAS2224-77-3

pharmaceutical intermediate

ReferenceSame Category

4-(4-chlorophenyl)-1H-2,3-benzoxazin-1-one

CAS2224-83-1

pharmaceutical intermediate

Identifiers
IUPAC Name

N,N'-bis[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]oxamide

InChIKey

NMHSIKFQDIYZSG-VXKWHMMOSA-N

SMILES

C1COC[C@H]1OC2=C(C=C3C(=C2)N=CN=C3NC4=CC(=C(C=C4)F)Cl)NC(=O)C(=O)NC5=C(C=C6C(=C5)C(=NC=N6)NC7=CC(=C(C=C7)F)Cl)O[C@H]8CCOC8

Synonyms (2)

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