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Home/Compounds/Pharmaceutical Intermediate/2'-propargyl U amidite
C42H49N4O9P
784.8 g/mol
Pharmaceutical Intermediate

2'-propargyl U amidite

CAS171486-62-7
Category
Pharmaceutical Intermediate
Compound Class
Other
Primary Use
Pharmaceutical Intermediate

2'-propargyl U amidite is a phosphoramidite building block used in solid-phase RNA synthesis. Its structure includes a 2'-O-propargyl modification and a dimethoxytrityl (DMT) protecting group, making it suitable for incorporating modified uridine residues into synthetic oligonucleotides.

RNA synthesis phosphoramidite building blockModified oligonucleotide research

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

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Identifiers
IUPAC Name

3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-prop-2-ynoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChIKey

SKUHDLBLPLSZJC-CYSIDSPMSA-N

SMILES

CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCC#C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

Synonyms (5)
  • 2'-propargyl U amidite