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Home/Compounds/Pharmaceutical Intermediate/5'-O-DMT-2'-(2-methoxyethyl)uridine 3'-CE phosphoramidite
C42H53N4O10P
804.9 g/mol
Pharmaceutical Intermediate

5'-O-DMT-2'-(2-methoxyethyl)uridine 3'-CE phosphoramidite

CAS163759-97-5
Category
Pharmaceutical Intermediate
Compound Class
Other
Primary Use
Pharmaceutical Intermediate

This compound is a protected uridine phosphoramidite derivative used as a building block in the solid-phase synthesis of oligonucleotides. Its structure incorporates a 2'-O-(2-methoxyethyl) modification, a 5'-O-dimethoxytrityl protecting group, and a 3'-O-(diisopropylamino-2-cyanoethoxyphosphanyl) group, making it suitable for automated RNA synthesis in research and pharmaceutical manufacturing.

Oligonucleotide building block for solid-phase synthesisResearch reagent for RNA modification studies

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

StrongStructure SimilarSimilarity 0.90

Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-propyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)

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research compound

StrongStructure SimilarSimilarity 0.89

5'-O-(4,4-Dimethoxytrityl)-2'-O-methyluridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

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pharmaceutical intermediate

StrongStructure SimilarSimilarity 0.87

2'-propargyl U amidite

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StrongStructure SimilarSimilarity 0.86

2'-O-Hexadecyl-U-CE-Phosphoramidite

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pharmaceutical intermediate

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Identifiers
IUPAC Name

3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-(2-methoxyethoxy)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChIKey

ZLOKLUONKGURQI-UAQIPLLRSA-N

SMILES

CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCCOC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

Synonyms (10)
  • 2'-O-MOE-U
  • 2'-O-MOE-U-3'-phosphoramidite