MC-Val-Cit-PAB-OH is a peptide-like linker compound used as a pharmaceutical intermediate in the manufacture of antibody-drug conjugates (ADCs). Its structure incorporates a valine-citrulline dipeptide, a maleimide group for antibody conjugation, and a para-aminobenzyl alcohol (PAB) self-immolative spacer, enabling controlled drug release.
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Mc-Val-Cit-PAB-Cl
pharmaceutical intermediate
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Dxd
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(3R)-3-[(2-methylpropan-2-yl)oxycarbonylamino]butanoic acid
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N-[(2S)-1-[[(2S)-5-(carbamoylamino)-1-[4-(hydroxymethyl)anilino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-6-(2,5-dioxopyrrol-1-yl)hexanamide
AMKBTTRWLGVRER-OFVILXPXSA-N
CC(C)[C@@H](C(=O)N[C@@H](CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)CCCCCN2C(=O)C=CC2=O
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