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Home/Compounds/Pharmaceutical Intermediate/5'-DMT-3'-O-TBDMS-PseudoUridine
C36H44N2O8Si
660.8 g/mol
Pharmaceutical Intermediate

5'-DMT-3'-O-TBDMS-PseudoUridine

CAS144429-58-3
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

This compound is a protected pseudouridine derivative used as a pharmaceutical intermediate in the synthesis of modified nucleosides. It features 5'-O-DMT and 3'-O-TBDMS protecting groups, along with a free 2'-hydroxyl group, making it suitable for oligonucleotide research and manufacturing.

pharmaceutical intermediate for modified nucleosidesbuilding block for oligonucleotide synthesis

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

StrongStructure SimilarSimilarity 0.88

5'-O-DMT-2'-O-TBDMS-Pseudouridine

CAS144429-56-1

pharmaceutical intermediate

SimilarStructure SimilarSimilarity 0.78

5'-DMT-PseudoUridine

CAS144429-55-0

pharmaceutical intermediate

SimilarStructure SimilarSimilarity 0.75

5'-O-(4,4'-dimethoxitrityl)-3'-O-(tert-butyldimethylsilyl)-1-methylpseudouridine

CAS875302-43-5

pharmaceutical intermediate

ReferenceSame Category

1,2,3,4-Tetrahydroisoquinolin-6-ol

CAS14446-24-3

pharmaceutical intermediate

ReferenceSame Category

1,2,3,5-Tetra-O-acetyl-beta-L-ribofuranose

CAS144490-03-9

pharmaceutical intermediate

ReferenceSame Category

(betaS)-beta-Aminobenzenepropanoic acid methyl ester hydrochloride

CAS144494-72-4

pharmaceutical intermediate

ReferenceSame Category

Pseudouridine

CAS1445-07-4

pharmaceutical intermediate

Referencesame scaffold

5'-O-(4,4'-Dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-1-N-methylpseudouridine

CAS875302-41-3

pharmaceutical intermediate

Identifiers
IUPAC Name

5-[(2S,3S,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-3-hydroxyoxolan-2-yl]-1H-pyrimidine-2,4-dione

InChIKey

GXZZSZUMLJWQRM-OKDNLZPVSA-N

SMILES

CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O[C@H]([C@@H]1O)C2=CNC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

Synonyms (2)

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