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Home/Compounds/Pharmaceutical Intermediate/5'-O-DMT-2'-O-TBDMS-Pseudouridine
C36H44N2O8Si
660.8 g/mol
Pharmaceutical Intermediate

5'-O-DMT-2'-O-TBDMS-Pseudouridine

CAS144429-56-1
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

This compound is a protected pseudouridine derivative used as a pharmaceutical intermediate in nucleoside synthesis. It features a dimethoxytrityl (DMT) protecting group at the 5' position and a tert-butyldimethylsilyl (TBDMS) group at the 2' position, enabling selective chemical modifications during RNA-related research and manufacturing.

Pharmaceutical intermediate for nucleoside synthesisBuilding block for modified RNA oligonucleotides

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Identifiers
IUPAC Name

5-[(2S,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-1H-pyrimidine-2,4-dione

InChIKey

ZWMZNCKRGUDPLZ-FEFKUCBWSA-N

SMILES

CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H]([C@H](O[C@H]1C2=CNC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O

Synonyms (2)

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