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Home/Compounds/Pharmaceutical Intermediate/N(alpha)-t-butoxycarbonyl-L-leucine
C11H21NO4
231.29 g/mol
Pharmaceutical IntermediateWarning

Tert-Butoxycarbonyl-L-leucine

CAS13139-15-6EC236-073-2
Category
Pharmaceutical Intermediate
Compound Class
Amide
Primary Use
Pharmaceutical Intermediate

tert-Butoxycarbonyl-L-leucine (Boc-Leu-OH) is a derivative of the amino acid L-leucine, where the amino group is protected by a tert-butoxycarbonyl (Boc) group. It is widely used as a building block in solid-phase peptide synthesis, enabling the sequential assembly of peptides while preventing unwanted side reactions at the amine site.

Peptide synthesis intermediateBuilding block for solid-phase peptide synthesis

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

ApplicationSame Use

Tert-butyl (S)-(1-cyclopropyl-2-hydroxyethyl)carbamate

CAS1360774-41-9

pharmaceutical intermediate

ApplicationSame Use

Boc-L-Glutamic acid

CAS2419-94-5

pharmaceutical intermediate

ApplicationSame Use

N-Boc-N'-tosyl-L-arginine

CAS13836-37-8

pharmaceutical intermediate

ApplicationSame Use

Fmoc-His-Aib-OH

CAS1446013-07-5

pharmaceutical intermediate

ReferenceSame Category

Boc-L-Isoleucine

CAS13139-16-7

pharmaceutical intermediate

ReferenceSame Category

Zinc peroxide

CAS1314-22-3

pharmaceutical intermediate

ReferenceSame Category

(3R,4R)-1-Boc-4-fluoro-3-piperidinol

CAS1314641-02-5

pharmaceutical intermediate

ReferenceSame Category

3,5-TIPS-N-PAc-Guanosine

CAS131474-72-1

pharmaceutical intermediate

Safety Reference

Harmful
Harmful
Warning
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Customs Tariff Classification

The international HS code for Tert-Butoxycarbonyl-L-leucine (CAS 13139-15-6) is 2924.19.

HS code (international, 6-digit)

2924.19

EU CN code (8-digit)

2924 19 00

Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.

Identifiers
IUPAC Name

(2S)-4-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanoic acid

InChIKey

MDXGYYOJGPFFJL-QMMMGPOBSA-N

SMILES

CC(C)C[C@@H](C(=O)O)NC(=O)OC(C)(C)C

Synonyms (46)
  • (S)-N-BOC-T-LEUCINE
  • Boc-L-Leu-OH
  • Boc-L-Leucine monohydrate
  • Boc-L-leucine
  • Boc-Leu-OH
  • Boc-Leu-OH monohydrate
  • Boc-Leu-OH, >=99.0% (HPLC)
  • BocLeucine
  • L-Leucine, N-BOC protected
  • N-Boc-L-leucine
  • N-Boc-Leu-OH
  • N-Boc-Leucine hydrate
  • N-Boc-leucine
  • N-t-butoxycarbonyl-L-leucine
  • N-t-butoxycarbonylleucine
  • N-t-butyloxycarbonyl-l-leu
  • N-tert-Butoxycarbonylleucine
  • boc-leu
  • t-Butyloxycarbonyl-L-Leucine
  • t-butoxycarbonyl-leucine
  • tert-Butoxycarbonyl-L-leucine
  • tert-Butoxycarbonylleucine
  • tert-Butyloxycarbonylleucine

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