C32H33ClFN5O11
718.1 g/mol
APIDanger
AFATINIB DIMALEATE
CAS850140-73-7
Category
API
Compound Class
Amide
Primary Use
Pharmaceutical Raw Material
Afatinib dimaleate is the maleate salt form of afatinib, a tyrosine kinase inhibitor. It is used as a pharmaceutical raw material in the manufacturing of antineoplastic agents.
Pharmaceutical raw material for antineoplastic drug productsIntermediate in the synthesis of tyrosine kinase inhibitor formulations
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
StrongSame Parent
N-[4-(3-chloro-4-fluoroanilino)-7-[[(3S)-3-oxolanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
CAS439081-18-2
pharmaceutical raw material
StrongSame Parent
Afatinib
CAS850140-72-6
pharmaceutical raw material
ReferenceSame Category
Alogliptin
CAS850649-61-5
pharmaceutical raw material
ReferenceSame Category
Alogliptin benzoate
CAS850649-62-6
pharmaceutical raw material
ReferenceSame Category
Citalopram hydrochloride
CAS85118-27-0
pharmaceutical raw material
ReferenceSame Category
Linaclotide
CAS851199-59-2
pharmaceutical raw material
Referencestereoisomer of
Afatinib, (R)-
CAS945553-91-3
pharmaceutical raw material
Referencestereoisomer of
Afatinib D6
CAS1313874-96-2
pharmaceutical raw material
Safety Reference
Danger
H302Harmful if swallowed
H319Causes serious eye irritation
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
H372Causes damage to organs through prolonged or repeated exposure
H373May cause damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
Customs Tariff Classification
The international HS code for AFATINIB DIMALEATE (CAS 850140-73-7) is 2934.99.
HS code (international, 6-digit)
2934.99
EU CN code (8-digit)
2934 99 90
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
bis((Z)-but-2-enedioic acid);(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
InChIKey
USNRYVNRPYXCSP-JUGPPOIOSA-N
SMILES
CN(C/C=C/C(=O)NC1=C(C=C2N=CN=C(C2=C1)NC3=CC(=C(C=C3)F)Cl)O[C@@H]4COCC4)C.C(=C\C(=O)O)\C(=O)O.C(=C\C(=O)O)\C(=O)O
Synonyms (19)
- Afatinib dimaleate (USAN)
- 850140-73-7 (dimaleate)
- AFATINIB DIMALEATE
- Afatinib (BIBW2992) Dimaleate
- Afatinib maleate
- Afatinib maleate (JAN)
- BIBW 2992MA2
- Gilotrif
- Gilotrif (TN)
- Giotrif
- Giotrif (TN)
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