C24H25ClFN5O3
485.9 g/mol
APIWarning
Afatinib
CAS850140-72-6EC810-720-4
Category
API
Compound Class
Amine
Primary Use
Pharmaceutical Raw Material
Afatinib is a pharmaceutical raw material used in the manufacturing of active pharmaceutical ingredients for research and development. It is a tyrosine kinase inhibitor compound commonly supplied to pharmaceutical and biotechnology laboratories.
Non-small cell lung carcinoma researchTyrosine kinase inhibitor developmentPharmaceutical manufacturing intermediate
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
StrongSame Parent
Afatinib dimaleate
CAS850140-73-7
pharmaceutical raw material
StrongSame Parent
N-[4-(3-chloro-4-fluoroanilino)-7-[[(3S)-3-oxolanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide
CAS439081-18-2
pharmaceutical raw material
ReferenceSame Category
Alogliptin
CAS850649-61-5
pharmaceutical raw material
ReferenceSame Category
Alogliptin benzoate
CAS850649-62-6
pharmaceutical raw material
ReferenceSame Category
Citalopram hydrochloride
CAS85118-27-0
pharmaceutical raw material
ReferenceSame Category
Linaclotide
CAS851199-59-2
pharmaceutical raw material
Referencestereoisomer of
Afatinib, (R)-
CAS945553-91-3
pharmaceutical raw material
Referencestereoisomer of
Afatinib D6
CAS1313874-96-2
pharmaceutical raw material
Safety Reference
Warning
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H373May cause damage to organs through prolonged or repeated exposure
Customs Tariff Classification
The international HS code for Afatinib (CAS 850140-72-6) is 2934.99.
HS code (international, 6-digit)
2934.99
EU CN code (8-digit)
2934 99 90
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide
InChIKey
ULXXDDBFHOBEHA-CWDCEQMOSA-N
SMILES
CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4
Synonyms (34)
- Afatinib (USAN/INN)
- (E/Z)-Afatinib
- (E/Z)-Afatinib (Standard)
- (S)-Afatinib
- 850140-72-6 (free base)
- AFATINIB [MART.]
- Afatinib
- Afatinib (BIBW2992)
- Afatinib - Bio-X trade mark
- Afatinib E-Isomer
- Afatinib, Free Base
- BIBW 2992
- BIBW2992 (Tovok)
- BIBW2992,Afatinib
- Tomtovok
- Tovok
- afatinibum
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