C20H22N8O5
454.4 g/mol
APIDanger
Methotrexate
CAS59-05-2EC200-413-8
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Methotrexate is an active pharmaceutical ingredient (API) recognized as a folic acid antagonist. It can cause developmental toxicity according to an independent committee of scientific and health experts.
pharmaceutical raw material for severe, recalcitrant, disabling psoriasisinsect chemosterilant
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
Restricted or banned substances
Substances on this list are banned or restricted under the named regulation. This page is a compliance reference — verify your obligations under applicable law.
Relevant lists:California Proposition 65
CAS 59-05-2
Related Compounds
StrongStructure SimilarSimilarity 0.87
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Referencestereoisomer of
Methotrexate sodium
CAS7413-34-5
pharmaceutical raw material
Referencestereoisomer of
N-(4-{[(4-Amino-2-imino-2,3-dihydropteridin-6-yl)methyl][(²H₃)methyl]amino}benzoyl)glutamic acid
CAS432545-63-6
research compound
Referencesame scaffold
4-amino-4-deoxy-N10-methylpteroic acid
CAS19741-14-1
pharmaceutical intermediate
Safety Reference
Danger
H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H340May cause genetic defects
H360May damage fertility or the unborn child
Regulatory Compliance1
- California Proposition 65USRegulation
Customs Tariff Classification
The international HS code for Methotrexate (CAS 59-05-2) is 2933.59.
HS code (international, 6-digit)
2933.59
EU CN code (8-digit)
2933 59 95
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
(2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid
InChIKey
FBOZXECLQNJBKD-ZDUSSCGKSA-N
SMILES
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Synonyms (115)
- G-301
- JYLAMVO
- MTX
- R-9985
- Methotrexate (JP18/USP/INN)
- Methotrexate for peak identification, European Pharmacopoeia (EP)
- Methotrexate for system suitability, European Pharmacopoeia (EP)
- Methotrexate, European Pharmacopoeia (EP)
- Methotrexate, United States Pharmacopeia (USP)
- Methotrexatum [INN-Latin]
- Metotrexato [INN-Spanish]
- 1dhi
- 1dhj
- 2drc
- 4-Amino-10-methylfolic acid
- 4kn0
- 4ocx
- A-Methpterin
- Abitrexate (Methotrexate)
- Amethopterin
- Amethopterin L-
- Amethopterine
- Antifolan
- Brimexate
- Dicesium Salt Methotrexate
- EMT 25,299
- Ebetrex
- Emtexate
- Emtexate high-pot
- Emtexate pf
- Emthexat
- Emthexate
- Extexate;
- Farmitrexat
- Fauldexato
- Folex-Pfs
- Hdmtx
- Hydrate, Methotrexate
- Intradose-MTX
- L-Amethopterin
- Lantarel
- Ledertrexate
- Lumexon
- METHOTREXATE [MART.]
- Maxtrex
- Medsatrexate
- Metatrexan
- Metex
- Metex 6013
- Methoblastin
- Methotextrate
- Methotrexat
- Methotrexat-Ebewe
- Methotrexate (Standard)
- Methotrexate (hydrate)
- Methotrexate CRS
- Methotrexate RS
- Methotrexate, L-
- Methotrexatum
- Methylaminopterin
- Methylaminopterin; MTX
- Methylaminopterinum
- Metoject
- Metolate
- Metotressato
- Metotrexato
- Metrotex
- Mexate
- Nordimet
- Novatrex
- OTREXUP PFS
- Otrexup
- Otrexup (TN)
- Rasuvo
- Rheumatrex
- Texate
- Tremetex
- Trexeron
- Trixilem
- Xatmep
- Xatmep (TN)
- Zlatal
- [3H]methotrexate
- folic acid antagonist
- methotrexate