C15H15N7O2
325.33 g/mol
Pharmaceutical IntermediateDanger
DAMPA
CAS19741-14-1
Category
Pharmaceutical Intermediate
Compound Class
Amine
Primary Use
Pharmaceutical Intermediate
DAMPA (deoxyaminopteroic acid) is a metabolite formed by the carboxypeptidase-mediated cleavage of methotrexate. It is used as a marker for methotrexate exposure in research and analytical settings.
Marker for methotrexate exposure in researchPharmaceutical intermediate in methotrexate-related studies
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
ReferenceSame Category
4-Hydroxy-alpha-aminoacetophenone
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pharmaceutical intermediate
ReferenceSame Category
2-methyl-3-nitrobenzoic acid
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pharmaceutical intermediate
ReferenceSame Category
2-Methyl-5-nitrobenzoic acid
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pharmaceutical intermediate
ReferenceSame Category
Tert-butyl 4-((4-oxocyclohexyl)methyl)piperazine-1-carboxylate
CAS1975120-99-0
pharmaceutical intermediate
Referencesame scaffold
Methotrexate
CAS59-05-2
pharmaceutical raw material
Referencesame scaffold
Methotrexate 5-methyl ester
CAS67022-39-3
pharmaceutical intermediate
Referencesame scaffold
Methotrexate sodium
CAS7413-34-5
pharmaceutical raw material
Referencesame scaffold
N-(4-{[(4-Amino-2-imino-2,3-dihydropteridin-6-yl)methyl][(²H₃)methyl]amino}benzoyl)glutamic acid
CAS432545-63-6
research compound
Safety Reference
Danger
H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H360May damage fertility or the unborn child
Customs Tariff Classification
The international HS code for DAMPA (CAS 19741-14-1) is 2933.59.
HS code (international, 6-digit)
2933.59
EU CN code (8-digit)
2933 59 95
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoic acid
InChIKey
LWCXZSDKANNOAR-UHFFFAOYSA-N
SMILES
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)O
Synonyms (23)
- DAMPA
- Methotrexate EP Impurity E
- 2,4-Apa
- Deoxyaminopteroic acid
- METHOTREXATE IMPURITY E
- Methotrexate impurity E CRS
- Methotrexate metabolite
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