C15H15N7O2
325.33 g/mol
Pharmaceutical IntermediateDanger
DAMPA
CAS19741-14-1
Category
Pharmaceutical Intermediate
Compound Class
Amine
Primary Use
Pharmaceutical Intermediate
DAMPA (deoxyaminopteroic acid) is a metabolite formed by the carboxypeptidase-mediated cleavage of methotrexate. It is used as a marker for methotrexate exposure in research and analytical settings.
Marker for methotrexate exposure in researchPharmaceutical intermediate in methotrexate-related studies
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 19741-14-1
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Referencesame scaffold
N-(4-{[(4-Amino-2-imino-2,3-dihydropteridin-6-yl)methyl][(²H₃)methyl]amino}benzoyl)glutamic acid
CAS432545-63-6
research compound
Safety Reference
Danger
H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H360May damage fertility or the unborn child
Identifiers
IUPAC Name
4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoic acid
InChIKey
LWCXZSDKANNOAR-UHFFFAOYSA-N
SMILES
CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)O
Synonyms (23)
- DAMPA
- Methotrexate EP Impurity E
- 2,4-Apa
- Deoxyaminopteroic acid
- METHOTREXATE IMPURITY E
- Methotrexate impurity E CRS
- Methotrexate metabolite