C19H22ClNO4
363.8 g/mol
APIDanger
Naloxone hydrochloride
CAS357-08-4EC206-611-0
Category
API
Compound Class
Amine
Primary Use
Pharmaceutical Raw Material
Naloxone hydrochloride is a hydrochloride salt form of naloxone, an opioid antagonist. It is primarily used as a pharmaceutical raw material for reversing the effects of opioids, including in the management of opioid overdose.
pharmaceutical manufacturing for opioid reversal agentsactive ingredient in opioid antagonist formulations
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
StrongSame Parent
Naloxone hydrochloride dihydrate
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SimilarStructure SimilarSimilarity 0.79
Naloxone 3-Methyl Ether
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research compound
SimilarStructure SimilarSimilarity 0.75
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pharmaceutical raw material
SimilarStructure SimilarSimilarity 0.75
Naltrexone hydrochloride
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pharmaceutical raw material
ReferenceSame Category
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pharmaceutical raw material
ReferenceSame Category
Carboprost methyl
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pharmaceutical raw material
ReferenceSame Category
Pemetrexed disodium heptahydrate
CAS357166-29-1
pharmaceutical raw material
ReferenceSame Category
Pemetrexed disodium hemipentahydrate
CAS357166-30-4
pharmaceutical raw material
Safety Reference
Danger
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
Customs Tariff Classification
The international HS code for Naloxone hydrochloride (CAS 357-08-4) is 2939.19.
HS code (international, 6-digit)
2939.19
EU CN code (8-digit)
2939 19 00
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
(4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;hydrochloride
InChIKey
RGPDIGOSVORSAK-STHHAXOLSA-N
SMILES
C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl
Synonyms (59)
- NLX
- REXTOVY
- RIVIVE
- Naloxone Hydrochloride Injection, USP, Auto-Injector
- Naloxone hydrochloride (JP18/USP)
- 357-08-4 (HCl)
- EVZIO (AUTOINJECTOR)
- EVZIO(R) NALOXONE HCl
- Evzio
- Evzio (TN)
- Hydrochloride, Naloxone
- NALOXONE HCI
- NARCAN NALOXONE HCI
- Nafoxone Hydrochloride
- Nalone
- Nalonee
- Naloxon hydrochloride
- Naloxone HCl
- Naloxone Hydrochloride Nasal
- Naloxone hydrochloride
- Nalxone Hydrochloride
- Narcan
- Narcan (TN)
- Narcan Naloxone HCL
- Narcan neonatal
- Narcanti
- Narconil
- Prenoxad
- Zimhi
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