Home/Compounds/API/N4-(3-chloro-4-fluorophenyl)-7-(((3S)-tetrahydro-3-furanyl)oxy)-4,6-quinazolinediamine
C18H16ClFN4O2
374.8 g/mol
APIWarning
N4-(3-chloro-4-fluorophenyl)-7-(((3S)-tetrahydro-3-furanyl)oxy)-4,6-quinazolinediamine
CAS314771-76-1
Category
API
Compound Class
Amine
Primary Use
Pharmaceutical Raw Material
This compound is a quinazoline derivative featuring an oxolan-3-yloxy substituent and a 3-chloro-4-fluorophenylamino group. It is primarily recognized as an active pharmaceutical ingredient metabolite.
Pharmaceutical raw material for metabolite synthesisResearch compound in pharmaceutical development
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 314771-76-1
Related Compounds
SimilarStructure SimilarSimilarity 0.85
(S)-N4-(3,4-Difluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
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pharmaceutical intermediate
SimilarStructure SimilarSimilarity 0.85
(S)-N4-(3,4-Dichlorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine
CAS2044709-79-5
pharmaceutical intermediate
SimilarStructure SimilarSimilarity 0.78
(S)-N4-(4-Fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine (Afatinib Impurity)
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Safety Reference
Warning
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
Identifiers
IUPAC Name
4-N-(3-chloro-4-fluorophenyl)-7-[(3S)-oxolan-3-yl]oxyquinazoline-4,6-diamine
InChIKey
BIQABKFYKJRXII-NSHDSACASA-N
SMILES
C1COC[C@H]1OC2=C(C=C3C(=C2)N=CN=C3NC4=CC(=C(C=C4)F)Cl)N
Synonyms (14)
- Afatinib Impurity B
- Afatinib metabolite M20