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Home/Compounds/API/Afatinib N-oxide
C24H25ClFN5O4
501.9 g/mol
API

Afatinib N-oxide

CAS2413212-11-8
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material

Afatinib N-oxide is an active pharmaceutical ingredient metabolite, specifically an oxidized derivative of afatinib. It is a quinazoline-based compound with an N-oxide functional group, characterized by aromatic rings, ether linkages, and halogen substituents.

Pharmaceutical reference standard for analytical testingImpurity profiling in afatinib manufacturing

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Identifiers
IUPAC Name

(E)-4-[[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]amino]-N,N-dimethyl-4-oxobut-2-en-1-amine oxide

InChIKey

IABSYXLQTGEUIV-CWDCEQMOSA-N

SMILES

C[N+](C)(C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4)[O-]

Synonyms (10)
  • AFATINIB METABOLITE M15
  • Afatinib Impurity K
  • Afatinib Impurity N-Oxide
  • afatinib N-oxide