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Home/Compounds/Pharmaceutical Intermediate/Methyl 16-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-2-(2,4-dioxopyrimidin-1-yl)tetrahydrofuran-3-yl]oxyhexadecanoate
C56H79N4O11P
1015.2 g/mol
Pharmaceutical Intermediate

Methyl 16-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-2-(2,4-dioxopyrimidin-1-yl)tetrahydrofuran-3-yl]oxyhexadecanoate

CAS2642320-25-8
Category
Pharmaceutical Intermediate
Compound Class
Heterocycle
Primary Use
Pharmaceutical Intermediate

This compound is a phosphoramidite building block used in oligonucleotide synthesis. It features a long-chain fatty acid ester moiety linked to a protected nucleoside via an ether bridge, along with a cyanoethyl phosphoramidite group for solid-phase DNA/RNA synthesis.

Phosphoramidite building block for oligonucleotide synthesisReagent for solid-phase DNA/RNA synthesisIntermediate for modified oligonucleotide manufacturing

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Identifiers
IUPAC Name

methyl 16-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxyhexadecanoate

InChIKey

NWFCOAVWTXVSHI-GWCNJYPESA-N

SMILES

CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCCCCCCCCCCCCCCCC(=O)OC)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

Synonyms (1)

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