C23H26Cl2N6O3
505.4 g/mol
APIWarning
Momelotinib dihydrochloride monohydrate
CAS1841094-17-4
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Momelotinib dihydrochloride monohydrate is a salt and hydrate form of momelotinib, an orally bioavailable small molecule that inhibits Janus kinases 1 and 2 (JAK1/2), the JAK2 mutant JAK2V617F, and activin A receptor type 1 (ACVR1/ALK2). It is used as an active pharmaceutical ingredient in the manufacture of pharmaceutical products, where its mechanism involves inhibition of the JAK-STAT signaling pathway and suppression of hepcidin formation.
Active pharmaceutical ingredient for pharmaceutical manufacturingResearch compound for JAK-STAT signaling pathway studies
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 1841094-17-4
Related Compounds
StrongSame Parent
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Referencesame scaffold
4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzoic acid
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pharmaceutical intermediate
Safety Reference
Warning
H302Harmful if swallowed
H373May cause damage to organs through prolonged or repeated exposure
Identifiers
IUPAC Name
N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide;hydrate;dihydrochloride
InChIKey
RQKCPSIFARJBOR-UHFFFAOYSA-N
SMILES
C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N.O.Cl.Cl
Synonyms (9)
- Ojjaara
- Ojjaara (TN)
- Omjjara (TN)