C25H26FN3O7S
531.6 g/mol
APIDanger
Exatecan mesilate
CAS169869-90-3
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Exatecan mesilate is a semisynthetic, water-soluble derivative of camptothecin and the mesylate salt form of exatecan. It functions as a topoisomerase I inhibitor, stabilizing the cleavable complex between topoisomerase I and DNA, thereby inhibiting DNA replication and inducing apoptotic cell death.
Active pharmaceutical ingredient for antineoplastic researchTopoisomerase I inhibitor in drug developmentPharmaceutical intermediate for camptothecin derivative production
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
StrongSame Parent
Exatecan
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StrongSame Parent
Exatecan hydrochloride
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SimilarStructure SimilarSimilarity 0.76
Dxd
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Safety Reference
Danger
H300Fatal if swallowed
H301Toxic if swallowed
H340May cause genetic defects
Identifiers
IUPAC Name
(10S,23S)-23-amino-10-ethyl-18-fluoro-10-hydroxy-19-methyl-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaene-5,9-dione;methanesulfonic acid
InChIKey
BICYDYDJHSBMFS-GRGFAMGGSA-N
SMILES
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C5[C@H](CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)N)O.CS(=O)(=O)O
Synonyms (9)
- Exatecan (Mesylate)
- Exatecan (mesylate) (GMP)
- Exatecan mesilate
- Exatecan mesylate anhydrous
- Exatecan mesylate salt
- Exatecan methanesulfonic acid
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