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Home/Compounds/API/(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one
C21H17ClF2N4O2
430.8 g/mol
API

(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one

CAS1698055-86-5
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material

ARS-1620 is a quinazoline derivative that acts as a potent and selective covalent inhibitor of the KRAS G12C mutant protein. It is an orally bioavailable compound used in pharmaceutical research for targeting tumors harboring the KRAS G12C mutation.

covalent KRAS G12C inhibitor for oncology researchresearch compound for studying KRAS mutant tumors

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

StrongSame Parent

(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one

CAS1698024-73-5

pharmaceutical raw material

StrongSame Parent

(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one

CAS1698055-85-4

pharmaceutical raw material

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pharmaceutical raw material

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pharmaceutical raw material

Identifiers
IUPAC Name

1-[4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one

InChIKey

ZRPZPNYZFSJUPA-UHFFFAOYSA-N

SMILES

C=CC(=O)N1CCN(CC1)C2=NC=NC3=C(C(=C(C=C32)Cl)C4=C(C=CC=C4F)O)F

Synonyms (11)
  • ARS-1323?
  • ARS-1620?
  • ARS-1630?
  • example 227