C43H55N4O10P
818.9 g/mol
Pharmaceutical IntermediateWarning
2'-O-MOE-5-Methyl-Uridine Phosphoramidite
CAS163878-63-5EC804-904-3
Category
Pharmaceutical Intermediate
Compound Class
Other
Primary Use
Pharmaceutical Intermediate
2'-O-MOE-5-Methyl-Uridine Phosphoramidite is a chemically modified phosphoramidite building block used as a pharmaceutical intermediate in oligonucleotide synthesis. It incorporates a 2'-O-(2-methoxyethyl) (MOE) modification and a 5-methyluridine base, which enhance the stability and binding properties of synthetic oligonucleotides for research applications.
Pharmaceutical intermediate for oligonucleotide synthesis manufacturingLaboratory reagent for nucleic acid research
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 163878-63-5
Related Compounds
SimilarStructure SimilarSimilarity 0.74
5'-Dimethoxytrityl-3'-deoxythymidine 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite
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SimilarStructure SimilarSimilarity 0.73
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SimilarStructure SimilarSimilarity 0.73
(2R,3R,4R,5R)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
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Safety Reference
Warning
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
Identifiers
IUPAC Name
3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
InChIKey
YFRRKZDUDXHJNC-KZQAAKLLSA-N
SMILES
CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OP(N(C(C)C)C(C)C)OCCC#N)OCCOC
Synonyms (23)
- 5-Me-DMT-2'-O-MOE-U-CE P
- DMT-2'-O-MOE-T-CEP