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Home/Compounds/Pharmaceutical Intermediate/(2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
C44H52N5O9P
825.9 g/mol
Pharmaceutical Intermediate

(2R,3R,4R,5R)-5-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

CAS1498305-51-3
Category
Pharmaceutical Intermediate
Compound Class
Other
Primary Use
Pharmaceutical Intermediate

This compound is a nucleoside phosphoramidite used as a building block in the chemical synthesis of oligonucleotides. It incorporates a protected acetylcytosine base, a propargyl ether group on the ribose, and a dimethoxytrityl (DMT) protecting group, along with a cyanoethyl phosphoramidite moiety for automated solid-phase DNA/RNA synthesis.

Building block for automated oligonucleotide synthesisIntermediate in the production of modified DNA or RNA sequences

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

StrongStructure SimilarSimilarity 0.87

N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

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pharmaceutical intermediate

SimilarStructure SimilarSimilarity 0.85

(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(hexadecyloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite

CAS2382942-38-1

research compound

SimilarStructure SimilarSimilarity 0.83

N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]cytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

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pharmaceutical intermediate

SimilarStructure SimilarSimilarity 0.82

N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-deoxy-2'-fluorocytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

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pharmaceutical intermediate

ApplicationSame Use

2'-O-Hexadecyl-U-CE-Phosphoramidite

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pharmaceutical intermediate

ApplicationSame Use

Ac-dA Phosphoramidite

CAS1027734-01-5

pharmaceutical intermediate

ApplicationSame Use

((((E)-2-((2R,3R,4R,5R)-3-(((2-CYANOETHOXY)(DIISOPROPYLAMINO)PHOSPHINO)OXY)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-METHOXYTETRAHYDROFURAN-2-YL)VINYL)PHOSPHORYL)BIS(OXY))BIS(METHYLENE) BIS(2,2-DIMETHYLPROPANOATE)

CAS2172373-55-4

pharmaceutical intermediate

ApplicationSame Use

3-[[(2R,3R,4R,5R)-2-[(1S)-1-[bis(4-methoxyphenyl)-phenyl-methoxy]ethyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxy-tetrahydrofuran-3-yl]oxy-(diisopropylamino)phosphanyl]oxypropanenitrile

CAS2747890-15-7

pharmaceutical intermediate

Identifiers
IUPAC Name

N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-prop-2-ynoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChIKey

JIMYWWYYWAHJAD-ZMHKPELYSA-N

SMILES

CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1OCC#C)N2C=CC(=NC2=O)NC(=O)C)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

Synonyms (5)
  • 2'-propargyl C(Ac) amidite

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