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Home/Compounds/Pharmaceutical Intermediate/3-[[(2R,3R,4R,5R)-2-[(1S)-1-[bis(4-methoxyphenyl)-phenyl-methoxy]ethyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxy-tetrahydrofuran-3-yl]oxy-(diisopropylamino)phosphanyl]oxypropanenitrile
C41H51N4O9P
774.8 g/mol
Pharmaceutical Intermediate

3-[[(2R,3R,4R,5R)-2-[(1S)-1-[bis(4-methoxyphenyl)-phenyl-methoxy]ethyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxy-tetrahydrofuran-3-yl]oxy-(diisopropylamino)phosphanyl]oxypropanenitrile

CAS2747890-15-7
Category
Pharmaceutical Intermediate
Compound Class
Amine
Primary Use
Pharmaceutical Intermediate

This compound is a nucleoside phosphoramidite building block designed for oligonucleotide synthesis. It features a DMT-protected 5'-hydroxyl group and a cyanoethyl phosphoramidite moiety at the 3'-position, enabling automated solid-phase DNA/RNA assembly.

Reagent for solid-phase oligonucleotide synthesisBuilding block for modified oligonucleotide probesResearch compound for nucleic acid chemistry

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Identifiers
IUPAC Name

3-[[(2R,3R,4R,5R)-2-[(1S)-1-[bis(4-methoxyphenyl)-phenylmethoxy]ethyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile

InChIKey

PKWBIYABXKYVJR-UYALASEFSA-N

SMILES

C[C@@H]([C@@H]1[C@H]([C@H]([C@@H](O1)N2C=CC(=O)NC2=O)OC)OP(N(C(C)C)C(C)C)OCCC#N)OC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

Synonyms (1)

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