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Home/Compounds/API/Sacubitril calcium
C48H56CaN2O10
861 g/mol
API

Sacubitril calcium

CAS1369773-39-6
Category
API
Compound Class
Amide
Primary Use
Pharmaceutical Raw Material

Sacubitril calcium is a calcium salt form of sacubitril, a prodrug that acts as a neprilysin inhibitor. Upon administration, it is metabolized to its active form, sacubitrilat, which inhibits neprilysin, an enzyme that degrades natriuretic peptides and certain vasoconstricting peptides.

active pharmaceutical ingredientpharmaceutical intermediate

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Related Compounds

StrongSame Parent

Ahu-377 sodium

CAS149690-05-1

pharmaceutical raw material

ReferenceSame Category

Pralidoxime chloride, (Z)-

CAS13698-37-8

pharmaceutical raw material

ReferenceSame Category

Lotilaner

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pharmaceutical raw material

ReferenceSame Category

Lidocaine

CAS137-58-6

pharmaceutical raw material

ReferenceSame Category

Amprolium chloride hydrochloride

CAS137-88-2

pharmaceutical raw material

Referencestereoisomer of

Sacubitril

CAS149709-62-6

pharmaceutical raw material

Referencestereoisomer of

Alpha-Ethyl (alphaS,gammaS)-gamma-((3-carboxy-1-oxopropyl)amino)-alpha-methyl(1,1'-biphenyl)-4-pentanoate

CAS149709-63-7

pharmaceutical raw material

Referencestereoisomer of

2R,4R-Sacubitril

CAS766480-48-2

pharmaceutical raw material

Identifiers
IUPAC Name

calcium bis(4-[[(2S,4R)-5-ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoate)

InChIKey

DDLCKLBRBPYKQS-OXXXZDCLSA-L

SMILES

CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].CCOC(=O)[C@H](C)C[C@@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)[O-].[Ca+2]

Synonyms (12)
  • AHU-377 Hemicalcium
  • AHU-377 calcium salt
  • AHU-377 hemicalcium salt
  • Sacubitril calcium
  • Sacubitril hemicalcium salt