C23H23N3O5
421.4 g/mol
APIDanger
Topotecan
CAS123948-87-8
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Topotecan is a pyranoindolizinoquinoline compound used as an antineoplastic agent. It is a derivative of camptothecin and functions by binding to the topoisomerase I-DNA complex, preventing the religation of single-strand breaks.
antineoplastic agenttopoisomerase I inhibitor
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 123948-87-8
Related Compounds
StrongSame Parent
Topotecan hydrochloride
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SimilarStructure SimilarSimilarity 0.79
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AGN-PC-07RIXJ
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Referencesame scaffold
10-hydroxycamptothecin
CAS19685-09-7
pharmaceutical raw material
Referencesame scaffold
9-aminocamptothecin
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pharmaceutical raw material
Safety Reference
Danger
H301Toxic if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H340May cause genetic defects
H341Suspected of causing genetic defects
Identifiers
IUPAC Name
(19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
InChIKey
UCFGDBYHRUNTLO-QHCPKHFHSA-N
SMILES
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC(=C5CN(C)C)O)N=C4C3=C2)O
Synonyms (39)
- Topotecane [INN-French]
- Topotecanum [INN-Latin]
- (S)-Topotecan
- Hycamptamine
- Hycamptin
- Hycamtamine
- Hycamtin (TN)
- Nogitecan
- SK&F 104864 A
- SK&F-104864
- SK&F-S-104864A
- SKF-S 104864
- TopoCED
- Topophore C
- Topotecan (BAN)
- Topotecan lactone
- Topotecane
- Topotecanum
- topotecan