C27H32F2N8
506.6 g/mol
APIDanger
Abemaciclib
CAS1231929-97-7EC806-670-8
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Abemaciclib is a cell cycle inhibitor that selectively targets cyclin-dependent kinases 4 and 6 (CDK4/6), with reported IC50 values of 2 nM and 10 nM in cell-free assays, respectively. It is a pharmaceutical raw material used in the manufacturing of kinase inhibitor-based products.
pharmaceutical raw material for CDK4/6 inhibitor productionresearch compound for cell cycle studies
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
StrongSame Parent
Abemaciclib mesylate
CAS1231930-82-7
pharmaceutical raw material
ReferenceSame Category
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CAS123246-29-7
pharmaceutical raw material
ReferenceSame Category
Clofarabine
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pharmaceutical raw material
ReferenceSame Category
5-trans-25-hydroxycholecalciferol
CAS1233749-00-2
pharmaceutical raw material
ReferenceSame Category
PUBCHEM_44134997
CAS123409-00-7
pharmaceutical raw material
Safety Reference
Danger
H360May damage fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
Customs Tariff Classification
The international HS code for Abemaciclib (CAS 1231929-97-7) is 2933.59.
HS code (international, 6-digit)
2933.59
EU CN code (8-digit)
2933 59 95
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
N-[5-[(4-ethylpiperazin-1-yl)methyl]-2-pyridinyl]-5-fluoro-4-(7-fluoro-2-methyl-3-propan-2-ylbenzimidazol-5-yl)pyrimidin-2-amine
InChIKey
UZWDCWONPYILKI-UHFFFAOYSA-N
SMILES
CCN1CCN(CC1)CC2=CN=C(C=C2)NC3=NC=C(C(=N3)C4=CC5=C(C(=C4)F)N=C(N5C(C)C)C)F
Synonyms (25)
- 6ZV
- Abemaciclib (JAN/USAN/INN)
- Abemaciclib
- Abemaciclib (Standard)
- Abemaciclib,LY2835219
- LY2835219 free base
- Verzenio
- Verzenio (TN)
- Verzenios
- abemaciclibum
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