C40H33N3O4
619.7 g/mol
Pharmaceutical IntermediateWarning
N-Fmoc-N'-trityl-L-histidine
CAS109425-51-6
Category
Pharmaceutical Intermediate
Compound Class
Peptide
Primary Use
Pharmaceutical Intermediate
This compound is a protected amino acid derivative used in peptide synthesis. Its significance lies in the orthogonal protection of the histidine side chain, enabling selective incorporation of histidine into synthetic peptides.
Peptide synthesis intermediateResearch reagent for solid-phase peptide synthesis
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 109425-51-6
Related Compounds
SimilarStructure SimilarSimilarity 0.81
Fmoc-His(Trt)-Gly-OH
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SimilarStructure SimilarSimilarity 0.80
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Referencestereoisomer of
N-Fmoc-N'-trityl-D-histidine
CAS135610-90-1
pharmaceutical intermediate
Safety Reference
Warning
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
Identifiers
IUPAC Name
(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid
InChIKey
XXMYDXUIZKNHDT-QNGWXLTQSA-N
SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=C(N=C4)C[C@@H](C(=O)O)NC(=O)OCC5C6=CC=CC=C6C7=CC=CC=C57
Synonyms (19)
- FMOC-HIS(1-TRT)-OH
- Fmoc-His(Trt)-OH
- N-Fmoc-N'-trityl-L-histidine
- fmoc-n-im-trityl-l-histidine