C40H33N3O4
619.7 g/mol
Pharmaceutical IntermediateWarning
(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid
CAS135610-90-1EC690-800-1
Category
Pharmaceutical Intermediate
Compound Class
Peptide
Primary Use
Pharmaceutical Intermediate
Fmoc-D-His(1-Trt)-OH is a protected amino acid derivative featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group and a trityl (Trt) side-chain protection on the histidine imidazole ring. It is primarily used as a building block in solid-phase peptide synthesis, enabling the sequential assembly of peptides with controlled stereochemistry.
Protected amino acid for peptide synthesisBuilding block in solid-phase peptide synthesis
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 135610-90-1
Related Compounds
SimilarStructure SimilarSimilarity 0.81
Fmoc-His(Trt)-Gly-OH
CAS1428125-83-0
research compound
SimilarStructure SimilarSimilarity 0.80
(S)-2-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoic acid
CAS1446013-13-3
research compound
ReferenceSame Category
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Rimegepant Impurity 104
CAS1356400-55-9
pharmaceutical intermediate
Referencestereoisomer of
N-Fmoc-N'-trityl-L-histidine
CAS109425-51-6
pharmaceutical intermediate
Safety Reference
Warning
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H413May cause long lasting harmful effects to aquatic life
Identifiers
IUPAC Name
(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid
InChIKey
XXMYDXUIZKNHDT-DIPNUNPCSA-N
SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=C(N=C4)C[C@H](C(=O)O)NC(=O)OCC5C6=CC=CC=C6C7=CC=CC=C57
Synonyms (17)
- 99% contains 3%CH2Cl2
- FMOC-D-HIS(TRT)-OH
- Fmoc-N(im)-trityl-D-histidine
- N-Fmoc-1-trityl-D-histidine
- N-Fmoc-N'-trityl-D-histidine
- fmoc-d-his(1-trt)-oh