C40H33N3O4
619.7 g/mol
Pharmaceutical IntermediateWarning
(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid
CAS135610-90-1EC690-800-1
Category
Pharmaceutical Intermediate
Compound Class
Peptide
Primary Use
Pharmaceutical Intermediate
Fmoc-D-His(1-Trt)-OH is a protected amino acid derivative featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group and a trityl (Trt) side-chain protection on the histidine imidazole ring. It is primarily used as a building block in solid-phase peptide synthesis, enabling the sequential assembly of peptides with controlled stereochemistry.
Protected amino acid for peptide synthesisBuilding block in solid-phase peptide synthesis
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
SimilarStructure SimilarSimilarity 0.81
Fmoc-His(Trt)-Gly-OH
CAS1428125-83-0
research compound
SimilarStructure SimilarSimilarity 0.80
(S)-2-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoic acid
CAS1446013-13-3
research compound
ReferenceSame Category
4-(Boc-Aminomethyl)piperidine
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ReferenceSame Category
1-[(benzyloxy)carbonyl]-5,5-difluoropiperidine-3-carboxylic acid
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pharmaceutical intermediate
ReferenceSame Category
2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride
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ReferenceSame Category
Rimegepant Impurity 104
CAS1356400-55-9
pharmaceutical intermediate
Referencestereoisomer of
N-Fmoc-N'-trityl-L-histidine
CAS109425-51-6
pharmaceutical intermediate
Related Reading
Safety Reference
Warning
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H413May cause long lasting harmful effects to aquatic life
Identifiers
IUPAC Name
(2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1-tritylimidazol-4-yl)propanoic acid
InChIKey
XXMYDXUIZKNHDT-DIPNUNPCSA-N
SMILES
C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=C(N=C4)C[C@H](C(=O)O)NC(=O)OCC5C6=CC=CC=C6C7=CC=CC=C57
Synonyms (17)
- 99% contains 3%CH2Cl2
- FMOC-D-HIS(TRT)-OH
- Fmoc-N(im)-trityl-D-histidine
- N-Fmoc-1-trityl-D-histidine
- N-Fmoc-N'-trityl-D-histidine
- fmoc-d-his(1-trt)-oh
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