C29H27F3N6O
532.6 g/mol
APIDanger
Ponatinibum
CAS943319-70-8EC851-222-7
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Ponatinibum is a multi-target tyrosine kinase inhibitor designed to overcome resistance to imatinib, particularly the BCR-ABL T315I gatekeeper mutation, and is used as an active pharmaceutical ingredient in the manufacture of antineoplastic agents.
Pharmaceutical raw materialResearch compound for tyrosine kinase inhibition
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
StrongSame Parent
Ponatinib hydrochloride
CAS1114544-31-8
pharmaceutical raw material
ReferenceSame Category
Selumetinib sulfate
CAS943332-08-9
pharmaceutical raw material
ReferenceSame Category
OMO-1
CAS943540-74-7
pharmaceutical raw material
ReferenceSame Category
Peficitinib
CAS944118-01-8
pharmaceutical raw material
ReferenceSame Category
Afatinib, (R)-
CAS945553-91-3
pharmaceutical raw material
Safety Reference
Danger
H301Toxic if swallowed
H311Toxic in contact with skin
H331Toxic if inhaled
H372Causes damage to organs through prolonged or repeated exposure
Customs Tariff Classification
The international HS code for Ponatinibum (CAS 943319-70-8) is 2933.59.
HS code (international, 6-digit)
2933.59
EU CN code (8-digit)
2933 59 95
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
InChIKey
PHXJVRSECIGDHY-UHFFFAOYSA-N
SMILES
CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Synonyms (16)
- 0LI
- Ponatinib (USAN/INN)
- 943319-70-8 (free base)
- AP 2453 4
- AP24534,Ponatinib
- Ponatinib
- Ponatinib (AP24534)
- Ponatinib (Standard)
- ponatinibum
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