C29H27F3N6O
532.6 g/mol
APIDanger
Ponatinibum
CAS943319-70-8EC851-222-7
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Ponatinibum is a multi-target tyrosine kinase inhibitor designed to overcome resistance to imatinib, particularly the BCR-ABL T315I gatekeeper mutation, and is used as an active pharmaceutical ingredient in the manufacture of antineoplastic agents.
Pharmaceutical raw materialResearch compound for tyrosine kinase inhibition
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 943319-70-8
Related Compounds
StrongSame Parent
Ponatinib hydrochloride
CAS1114544-31-8
pharmaceutical raw material
ReferenceSame Category
Selumetinib sulfate
CAS943332-08-9
pharmaceutical raw material
ReferenceSame Category
OMO-1
CAS943540-74-7
pharmaceutical raw material
ReferenceSame Category
Peficitinib
CAS944118-01-8
pharmaceutical raw material
ReferenceSame Category
Afatinib, (R)-
CAS945553-91-3
pharmaceutical raw material
Safety Reference
Danger
H301Toxic if swallowed
H311Toxic in contact with skin
H331Toxic if inhaled
H372Causes damage to organs through prolonged or repeated exposure
Identifiers
IUPAC Name
3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide
InChIKey
PHXJVRSECIGDHY-UHFFFAOYSA-N
SMILES
CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5
Synonyms (16)
- 0LI
- Ponatinib (USAN/INN)
- 943319-70-8 (free base)
- AP 2453 4
- AP24534,Ponatinib
- Ponatinib
- Ponatinib (AP24534)
- Ponatinib (Standard)
- ponatinibum