C29H28ClF3N6O
569 g/mol
APIDanger
Ponatinib hydrochloride
CAS1114544-31-8
Category
API
Compound Class
Amine
Primary Use
Pharmaceutical Raw Material
Ponatinib hydrochloride is the hydrochloride salt of ponatinib, a potent pan-inhibitor of tyrosine kinases that is active against all single resistance ABL kinase mutations, including the T315I mutation. It is an antineoplastic agent used in pharmaceutical manufacturing and research for chronic myeloid leukemia.
Pharmaceutical raw material for tyrosine kinase inhibitor formulationsResearch compound for ABL kinase mutation studies
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
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5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
CAS111542-93-9
pharmaceutical raw material
Safety Reference
Danger
H301Toxic if swallowed
H302Harmful if swallowed
H351Suspected of causing cancer
H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
Customs Tariff Classification
The international HS code for Ponatinib hydrochloride (CAS 1114544-31-8) is 2933.59.
HS code (international, 6-digit)
2933.59
EU CN code (8-digit)
2933 59 95
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide;hydrochloride
InChIKey
BWTNNZPNKQIADY-UHFFFAOYSA-N
SMILES
CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5.Cl
Synonyms (20)
- Ponatinib hydrochloride (JAN/USAN)
- 1114544-31-8 (HCl)
- 943319-70-8 free base
- AP 24534 hydrochloride
- AP24534 HCL
- Iclusig
- Iclusig (TN)
- Ponatinib (2 x HCl Salt)
- Ponatinib (HCl salt)
- Ponatinib HCl
- Ponatinib Mono-hydrochloride
- Ponatinib hydrochloride
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