C17H18N6
306.4 g/mol
APIWarning
Ruxolitinib
CAS941678-49-5EC107-728-9
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Ruxolitinib is a small-molecule inhibitor of Janus kinases (JAK1 and JAK2), used as an active pharmaceutical ingredient in pharmaceutical manufacturing. It is characterized by a pyrazole ring substituted with a pyrrolopyrimidine group and a nitrile-containing side chain.
Pharmaceutical raw material for JAK inhibitor formulationsCompound used in the manufacturing of myelofibrosis therapies
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 941678-49-5
Related Compounds
StrongSame Parent
(betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile maleate
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StrongSame Parent
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StrongSame Parent
Ruxolitinib hydrochloride
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Referencestereoisomer of
(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
CAS941685-37-6
pharmaceutical raw material
Safety Reference
Warning
H361Suspected of damaging fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
Identifiers
IUPAC Name
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
InChIKey
HFNKQEVNSGCOJV-OAHLLOKOSA-N
SMILES
C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
Synonyms (22)
- RXT
- Ruxolitinib (USAN/INN)
- (R)-Ruxolitinib (>90%)
- INCB 018424
- INCB18424,Ruxolitinib
- Oral JAK Inhibitor INCB18424
- R-Ruxolitinib
- Ruxolitinib
- Ruxolitinib (INCB018424)
- Ruxolitinib (Standard)
- Ruxolitinib, S-
- ruxolitinibum