C17H18N6
306.4 g/mol
APIWarning
Ruxolitinib
CAS941678-49-5EC107-728-9
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Ruxolitinib is a small-molecule inhibitor of Janus kinases (JAK1 and JAK2), used as an active pharmaceutical ingredient in pharmaceutical manufacturing. It is characterized by a pyrazole ring substituted with a pyrrolopyrimidine group and a nitrile-containing side chain.
Pharmaceutical raw material for JAK inhibitor formulationsCompound used in the manufacturing of myelofibrosis therapies
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
StrongSame Parent
(betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile maleate
CAS1092939-15-5
research compound
StrongSame Parent
Ruxolitinib phosphate
CAS1092939-17-7
pharmaceutical raw material
StrongSame Parent
Ruxolitinib hydrochloride
CAS1912373-07-9
pharmaceutical raw material
ReferenceSame Category
Tegoprazan
CAS942195-55-3
pharmaceutical raw material
ReferenceSame Category
(4R)-Tegoprazan
CAS942195-56-4
pharmaceutical raw material
ReferenceSame Category
Tolvaptan sodium phosphate
CAS942619-79-6
pharmaceutical raw material
ReferenceSame Category
Etilefrine hydrochloride
CAS943-17-9
pharmaceutical raw material
Referencestereoisomer of
(3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile
CAS941685-37-6
pharmaceutical raw material
Safety Reference
Warning
H361Suspected of damaging fertility or the unborn child
H373May cause damage to organs through prolonged or repeated exposure
Customs Tariff Classification
The international HS code for Ruxolitinib (CAS 941678-49-5) is 2933.59.
HS code (international, 6-digit)
2933.59
EU CN code (8-digit)
2933 59 95
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
InChIKey
HFNKQEVNSGCOJV-OAHLLOKOSA-N
SMILES
C1CCC(C1)[C@@H](CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
Synonyms (22)
- RXT
- Ruxolitinib (USAN/INN)
- (R)-Ruxolitinib (>90%)
- INCB 018424
- INCB18424,Ruxolitinib
- Oral JAK Inhibitor INCB18424
- R-Ruxolitinib
- Ruxolitinib
- Ruxolitinib (INCB018424)
- Ruxolitinib (Standard)
- Ruxolitinib, S-
- ruxolitinibum
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