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Home/Compounds/API/Rolapitant hydrochloride hydrate
C25H29ClF6N2O3
555 g/mol
API

Rolapitant hydrochloride

CAS914462-92-3
Category
API
Compound Class
Amine
Primary Use
Pharmaceutical Raw Material

Rolapitant hydrochloride is a pharmaceutical raw material used as an antiemetic neurokinin-1 receptor antagonist. It is indicated for the prevention of delayed nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy.

antiemetic neurokinin-1 receptor antagonistprevention of delayed nausea and vomiting from emetogenic cancer chemotherapy

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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Identifiers
IUPAC Name

(5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one;hydrate;hydrochloride

InChIKey

GZQWMYVDLCUBQX-WVZIYJGPSA-N

SMILES

C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC[C@]2(CC[C@]3(CCC(=O)N3)CN2)C4=CC=CC=C4.O.Cl

Synonyms (24)
  • Rolapitant hydrochloride (USAN)
  • Rolapitant HCl
  • Rolapitant HCl hydrate
  • Rolapitant hcl h20
  • Rolapitant hydrochloride
  • Varubi
  • Varubi (TN)
  • rolapitant monohydrochloride