C25H26F6N2O2
500.5 g/mol
APIWarning
Rolapitant
CAS552292-08-7
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Rolapitant is a pharmaceutical active pharmaceutical ingredient (API) that functions as a selective NK1 receptor antagonist. It is used as an antiemetic in the management of chemotherapy-induced nausea and vomiting (CINV).
Antiemetic active pharmaceutical ingredient for chemotherapy-induced nausea and vomiting
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Related Compounds
StrongSame Parent
Rolapitant hydrochloride hydrate
CAS914462-92-3
pharmaceutical raw material
ReferenceSame Category
Propentofylline
CAS55242-55-2
pharmaceutical raw material
ReferenceSame Category
Praziquantel
CAS55268-74-1
pharmaceutical raw material
ReferenceSame Category
Tiamulin fumarate
CAS55297-96-6
pharmaceutical raw material
ReferenceSame Category
Beclomethasone dipropionate
CAS5534-09-8
pharmaceutical raw material
Safety Reference
Warning
H361Suspected of damaging fertility or the unborn child
Customs Tariff Classification
The international HS code for Rolapitant (CAS 552292-08-7) is 2933.79.
HS code (international, 6-digit)
2933.79
EU CN code (8-digit)
2933 79 00
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
(5S,8S)-8-[[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]methyl]-8-phenyl-1,9-diazaspiro[4.5]decan-2-one
InChIKey
FIVSJYGQAIEMOC-ZGNKEGEESA-N
SMILES
C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)OC[C@]2(CC[C@]3(CCC(=O)N3)CN2)C4=CC=CC=C4
Synonyms (17)
- Rolapitant (USAN/INN)
- 5552292-08-7 (free base)
- Rolapitant
- Rolapitant (Standard)
- Rolapitant free base
- Rolapitant(sch619734)
- Sch 619734
- Varubi
- Varubi (TN)
- Varuby
- rolapitantum
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