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Home/Compounds/Pharmaceutical Intermediate/Doripenem side-chain
C20H28N4O9S2
532.6 g/mol
Pharmaceutical Intermediate

(4-Nitrophenyl)methyl (2S,4S)-4-(acetylthio)-2-(((aminosulfonyl)((1,1-dimethylethoxy)carbonyl)amino)methyl)-1-pyrrolidinecarboxylate

CAS491878-06-9
Category
Pharmaceutical Intermediate
Compound Class
Ester
Primary Use
Pharmaceutical Intermediate

This compound is a pharmaceutical intermediate specifically used as a side-chain building block in the manufacture of doripenem. It features a pyrrolidine core with acetylsulfanyl and sulfamoylamino substituents, protected by a tert-butoxycarbonyl group and a 4-nitrophenylmethyl ester.

Intermediate in doripenem manufacturingSide-chain precursor for carbapenem antibiotics

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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CAS 491878-06-9

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Identifiers
IUPAC Name

(4-nitrophenyl)methyl (2S,4S)-4-acetylsulfanyl-2-[[(2-methylpropan-2-yl)oxycarbonyl-sulfamoylamino]methyl]pyrrolidine-1-carboxylate

InChIKey

JECWBBGYVBPHIH-IRXDYDNUSA-N

SMILES

CC(=O)S[C@H]1C[C@H](N(C1)C(=O)OCC2=CC=C(C=C2)[N+](=O)[O-])CN(C(=O)OC(C)(C)C)S(=O)(=O)N

Synonyms (10)
  • Doripenem side-chain