Home/Compounds/Pharmaceutical Intermediate/Tert-Butyl [(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-yl]carbamate
C21H23F6N5O3
507.4 g/mol
Pharmaceutical IntermediateWarning
N-Boc-Sitagliptin
CAS486460-23-5
Category
Pharmaceutical Intermediate
Compound Class
Amide
Primary Use
Pharmaceutical Intermediate
N-Boc-Sitagliptin is a pharmaceutical intermediate used in the synthesis of sitagliptin. It is a tert-butyl carbamate derivative featuring a triazolopyrazine ring and multiple fluorine substituents, designed for controlled incorporation during the manufacturing process.
intermediate for sitagliptin synthesis
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 486460-23-5
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Safety Reference
Warning
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H373May cause damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
Identifiers
IUPAC Name
tert-butyl N-[(2R)-4-oxo-4-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-1-(2,4,5-trifluorophenyl)butan-2-yl]carbamate
InChIKey
RHCVXZBZEKGRQP-GFCCVEGCSA-N
SMILES
CC(C)(C)OC(=O)N[C@H](CC1=CC(=C(C=C1F)F)F)CC(=O)N2CCN3C(=NN=C3C(F)(F)F)C2
Synonyms (14)
- N-Boc-Sitagliptin
- Sitagliptin Impurity 22
- Sitagliptin N-Boc Impurity