C20H24O6
360.4 g/mol
APIDanger
Triptolide
CAS38748-32-2EC683-214-2
Category
API
Compound Class
Natural Product
Primary Use
Pharmaceutical Raw Material
Triptolide is a diterpenoid epoxide derived from the thunder god vine (Tripterygium wilfordii). It has shown activity in preclinical models of polycystic kidney disease and pancreatic cancer, but its clinical development is limited by severe toxicity and unfavorable physical properties, leading to the study of a water-soluble prodrug, minnelide.
research compound for polycystic kidney disease studiesresearch compound for pancreatic cancer studies
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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CAS 38748-32-2
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Referencestereoisomer of
14-epi-triptolide
CAS144539-79-7
research compound
Safety Reference
Danger
H300Fatal if swallowed
H330Fatal if inhaled
H301Toxic if swallowed
H361Suspected of damaging fertility or the unborn child
Identifiers
IUPAC Name
(1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-propan-2-yl-3,6,10,16-tetraoxaheptacyclo[11.7.0.02,4.02,9.05,7.09,11.014,18]icos-14(18)-en-17-one
InChIKey
DFBIRQPKNDILPW-CIVMWXNOSA-N
SMILES
CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C
Synonyms (6)
- Triptolid
- Triptolide, 1
- triptolide