C29H29N9O2
535.6 g/mol
APIDanger
N-(1-(8-((3-methyl-4-((1-methyl-1H-benzo[d]imidazol-5-yl)oxy)phenyl)amino)pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl)acrylamide
CAS2728667-27-2EC884-819-6
Category
API
Compound Class
Heterocycle
Primary Use
Pharmaceutical Raw Material
Zongertinib is a pharmaceutical raw material that functions as a selective, irreversible inhibitor of the HER2 tyrosine kinase. It covalently binds to the HER2 receptor, including exon 20 insertions, while sparing wild-type EGFR to reduce associated toxicities.
API for HER2-targeted kinase inhibitor formulationsCompound for manufacturing non-small cell lung cancer therapeutics
Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.
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Safety Reference
Danger
H360May damage fertility or the unborn child
H361Suspected of damaging fertility or the unborn child
H372Causes damage to organs through prolonged or repeated exposure
H413May cause long lasting harmful effects to aquatic life
Customs Tariff Classification
The international HS code for N-(1-(8-((3-methyl-4-((1-methyl-1H-benzo[d]imidazol-5-yl)oxy)phenyl)amino)pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl)acrylamide (CAS 2728667-27-2) is 2933.59.
HS code (international, 6-digit)
2933.59
EU CN code (8-digit)
2933 59 95
Classification per the EU customs inventory ECICS (2026-07 snapshot, HS 2022). National tariff lines and product form can affect the final classification.
Identifiers
IUPAC Name
N-[1-[4-[3-methyl-4-(1-methylbenzimidazol-5-yl)oxyanilino]pyrimido[5,4-d]pyrimidin-6-yl]piperidin-4-yl]prop-2-enamide
InChIKey
YSGNGFPNTLERCR-UHFFFAOYSA-N
SMILES
CC1=C(C=CC(=C1)NC2=NC=NC3=CN=C(N=C32)N4CCC(CC4)NC(=O)C=C)OC5=CC6=C(C=C5)N(C=N6)C
Synonyms (11)
- Zongertinib (JAN/USAN/INN)
- BI 1810631
- Hernexeos (TN)
- Zongertinib
- Zongertinib (BI 1810631)
- example I-01
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