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Home/Compounds/API/Belnacasan
C24H33ClN4O6
509 g/mol
API

VX-765

CAS273404-37-8
Category
API
Compound Class
Peptide
Primary Use
Pharmaceutical Raw Material

VX-765 is a dipeptide compound and the orally available prodrug of a potent and selective competitive inhibitor of ICE/caspase-1 (VRT-043198). It is being investigated as a pharmaceutical raw material for research in inflammatory and autoimmune conditions.

pharmaceutical raw material for research in inflammatory and autoimmune conditionsprodrug research compound for caspase-1 inhibition studies

Content scope: Information here supports chemical identification and industrial supply, research, and manufacturing contexts. It is not a therapeutic claim, medical advice, or drug-use instructions.

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2-[[(3aS,4R,6S,6aR)-4-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]oxy]ethanol

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Identifiers
IUPAC Name

(2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide

InChIKey

SJDDOCKBXFJEJB-MOKWFATOSA-N

SMILES

CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl

Synonyms (22)
  • VX-765
  • Belnacasan (USAN)
  • Belnacasan (USAN/INN)
  • Belnacasan
  • Belnacasan (VX-765)
  • VX-765 hemiketal
  • belcanasan
  • belnacasanum
  • vx-765 (Belnacasan)